Reducing Triglycerides And Remnant Cholesterol By 70% Showed No Effect On Plaque

A brand-new trial just presented at ACC 2026 is turning heads in cardiology, and not necessarily for the reason you'd expect. Researchers gave patients a powerful new drug that cut their triglycerides by nearly two-thi...

No Studies Show Berberine Lowers Cardiovascular Risk

There are no published randomized controlled trials demonstrating that berberine reduces major adverse cardiovascular events (MACE), cardiovascular mortality, or all-cause mortality. This represents a critical evidence gap: while berberine improv...

The Triglyceride Paradox: Why Lowering Triglycerides Hasn't Reduced Heart Disease

There are many ways to lower triglycerides, but most of them do not improve cardiovascular outcomes. However, there are a few things we can do to improve cardiovascular outcomes. We are going to dive deep into what wo...

All-Cause Mortality Is Not Always the Best Standard for Preventive Medicine

Every day on social media I get asked, "But what about all-cause mortality?". These Medfluencers and Healthfluencers seem to think that unless a study shows a reduction in All-Cause Mortality (ACM), then it is not a good st...

Treat Cholesterol, Earlier, Sooner, More Aggressively

For decades, we've accepted heart disease as an inevitable part of aging. Your grandfather had a heart attack at 60. Your father needed a stent at 55. Now you're wondering if you're next. But what if I told you that heart disease isn't actually ...

The 60 mg/dL Threshold: What the Science Really Says About LDL Cholesterol and Plaque Formation

For decades, the medical community has debated what constitutes an "optimal" LDL cholesterol level. While current guidelines recommend targets below 100 mg/dL for most people and below 70 mg/dL for high-...

The US and UK Diabetes Treatment Guidelines 2026 Update

Two major diabetes guideline updates landed within weeks of each other at the start of 2026: the American Diabetes Association (ADA) Standards of Care in Diabetes 2026 and the UK’s NICE guideline NG28, updated in February 2026. Together, they ...

Reverse Heart Disease? Is Plaque Regression Possible?

People ask me this all the time. "Dr. Alo, if I already have plaque in my arteries, is there any way to reverse it?"

For most of cardiology's history, the honest answer was: not really. We thought plaque was a one-way street. You build it up...

Are Heart Attacks Caused by Triglycerides, LDL, or Non-HDL? What the Latest Research Shows

When people search for the causes of heart disease or heart attacks, they often come across terms like triglycerides, LDL cholesterol, and non-HDL cholesterol. All three matter, but they do not appear to cont...

Cholesterol-Years: How Lifetime Cholesterol Exposure Affects Your Heart

What Are Cholesterol-Years?

Just like doctors measure smoking exposure in "pack-years," researchers have discovered that your lifetime exposure to cholesterol can be measured in "cholesterol-years." This number is calculated b...