New Oral PCSK9 Breakthrough Enlicitide (Lipfendra)

A new oral PCSK9 inhibitor called enlicitide decanoate just produced results in a major randomized trial that rival injectable therapies, and the cardiovascular world needs to pay attention. High levels of low-density lipoprotein cholesterol (LDL-C...

Best Congestive Heart Failure Treatment: What the Evidence Shows

Congestive heart failure used to have an 80% five-year mortality rate. This means that in 5 years, 80% of those diagnosed with CHF would be dead. That is no longer the case. Modern medications and therapeutics have been able to add 9 ...

Ozempic Cuts Heart Attacks and Strokes by 20 Percent In Non Diabetics

I have been a huge proponent of GLP1 medications since they first hit the market in 2005. I also run a cardiometabolic, obesity, and weight loss clinic and jumped on the modern GLP1 medications early in 2019. 

People think that ...

Why Most Heart Attacks Happen With Normal Cholesterol?

Every single day on social media, I get the same question: "Dr. Alo, if most people having heart attacks have normal cholesterol, then isn't cholesterol the real problem? Isn't it something else?" The answer is surprisingly simple, but online g...

The Metabolic "Grey Zone" in Young Adults: Why You Shouldn't Wait

What if you have "Pre Everything"? Pre-diabetes, pre-hypertension, pre-dyslipidemia. What's your risk? Should you wait until it gets worse?

A groundbreaking Korean nationwide study just revealed something that should shake up how we...

The History of Cholesterol: From Mummies and Gallstones to ApoB and Gene Editing

I have spent my career explaining cholesterol to patients, and one thing I have learned is that the whole subject makes far more sense when you understand how we got here. Cholesterol did not become controversial overn...

Is Low LDL Cholesterol Dangerous? What a Million-Person Genetic Study Reveals About Cholesterol and Lifespan

One of the most persistent myths I hear in my cardiology practice goes something like this: "Doctor, my cholesterol is low, but I read that low cholesterol shortens your life." It is a claim...

Why Do Desis Get So Much Heart Disease? A Cardiologist Explains.

Why people from India and Pakistan develop heart disease earlier, more often, and more severely than almost any other ethnic population on Earth, and what the actual science says you can do about it.

Let me tell you about a pattern I see...

What Is ApoB? A Cardiologist Explains Apolipoprotein B, the Best Predictor of Heart Attack Risk

Let me tell you the number I care about more than almost anything else on your lipid panel. It is not your LDL cholesterol. It is your ApoB, short for apolipoprotein B. If your doctor has told you your L...

Do Statins Help You Live Longer? What the Mortality Data Actually Shows

There is a version of the statin debate that lives entirely online, where the drugs are framed as a way to lower a number on a lab report without changing whether you actually live or die. It is a clever argument because it sou...